They are plug-n-play, no modification needed. Just make sure all the old gasket and sealer has been removed and that both surfaces are clean. No messy sealant required.
The 4/6 are a two piece design, a flat rubber piece that goes around all of the coolant passages, and a copper fire ring. The NOS Invader gaskets are a one piece similar to the Winderosa/Cometic/Kimpex. The Deere Liquifire used a two piece gasket, a fire ring similar to the 4/6 but the coolant seal was made of regular reinforced gasket material. It was coated with a white rubbery sealant.
Second to the 4/6 setup, I had the best luck with the Deere gaskets. I peeled the white coating off and used Dow sealant (I don't recall the number). It went around a hundred miles or so before leaking.